• 89. Cooperative, ion-sensitive co-assembly of tripeptide hydrogels

    Computational simulations and experimental validation of cooperative co-assembly of structural and functional tripeptides shows selective hydrogel formation in response to complexation with copper.

    Abul-Haija, Y. M.; Scott, G. G.; Sahoo, J. K.; Tuttle, T.; Ulijn, R. V.

    Chem. Commun. 2017 53 9562.

  • 88. Molecular dynamics simulations reveal disruptive self-assembly in dynamic peptide libraries

    There is significant interest in the use of unmodified self-assembling peptides as building blocks for functional, supramolecular biomaterials. Recently, dynamic peptide libraries (DPLs) have been proposed to select self-assembling materials from dynamically exchanging mixtures of dipeptide inputs in the presence of a nonspecific protease enzyme, where peptide sequences are selected and amplified based on their […]

    Sasselli, I. R.; Moreira, I. P.; Ulijn, R. V.; T. Tuttle, T.

    Org. Biomol. Chem. 2017 15 6541.

  • 86. Polymeric peptide pigments with sequence-encoded properties

    Melanins are a family of heterogeneous polymeric pigments that provide ultraviolet (UV) light protection, structural support, coloration, and free radical scavenging. Formed by oxidative oligomerization of catecholic small molecules, the physical properties of melanins are influenced by covalent and noncovalent disorder. We report the use of tyrosine-containing tripeptides as tunable precursors for polymeric pigments. In […]

    Lampel, A.; McPhee, S. A.; Park, H-A.; Scott, G. G.; Humagain, S.; Hekstra, D. R.; Barney Yoo, B.; Frederix, P. W. J. M.; Li, T-D.; Abzalimov, R. R.; Greenbaum, S. G.; Tuttle, T.; Hu, C.; Betting, C. J.; Ulijn, R. V.

    Science 2017 356 1064.

  • 85. Biocatalytic Self-Assembly of Tripeptide Gels and Emulsions

    We report on the biocatalytic activation of a self-assembling (unprotected) tripeptide to stabilize oil-in-water emulsions on-demand. This is achieved by the conversion of a phosphorylated precursor into a hydrogelator using alkaline phosphatase (AP) as the trigger. The rate of conversion, controlled by the amount of enzyme used, is shown to play a key role in […]

    Moreira, I. P.; Piskorz, T. K.; van Esch, J. H.; Tell Tuttle, T.; Ulijn, R. V.

    Langmuir 2017 33 4986.