• 80. Using experimental and computational energy equilibration to understand hierarchical self-assembly of Fmoc-dipeptide amphiphiles

    Despite progress, a fundamental understanding of the relationships between the molecular structure and self-assembly configuration of Fmoc-dipeptides is still in its infancy. In this work, we provide a combined experimental and computational approach that makes use of free energy equilibration of a number of related Fmoc-dipeptides to arrive at an atomistic model of Fmoc-threonine-phenylalanine-amide (Fmoc-TF-NH2) […]

    Sasselli, I. R.; Pappas, C. G.; Matthews, E.; Wang, T.; Hunt, N. T.; Ulijn, R. V.; Tuttle, T.

    Soft Matter 2016 12 8307.

  • 76. Supramolecular Fibers in Gels Can Be at Thermodynamic Equilibrium: A Simple Packing Model Reveals Preferential Fibril Formation versus Crystallization

    Low molecular weight gelators are able to form nanostructures, typically fibers, which entangle to form gel-phase materials. These materials have wide-ranging applications in biomedicine and nanotechnology. While it is known that supramolecular gels often represent metastable structures due to the restricted molecular dynamics in the gel state, the thermodynamic nature of the nanofibrous structure is […]

    Ivan Ramos Sasselli; Peter J. Halling; Rein V. Ulijn; Tell Tuttle

    ACS Nano 2016 10 2661.

  • 75. Enzymatically activated emulsions stabilised by interfacial nanofibre networks

    We report on-demand formation of emulsions stabilised by interfacial nanoscale networks. These are formed through biocatalytic dephosphorylation and self-assembly of Fmoc(9-fluorenylmethoxycarbonyl)dipeptide amphiphiles in aqueous/organic mixtures. This is achieved by using alkaline phosphatase which transforms surfactant-like phosphorylated precursors into self-assembling aromatic peptide amphiphiles (Fmoc-tyrosine-leucine, Fmoc-YL) that form nanofibrous networks. In biphasic organic/aqueous systems, these networks form […]

    Inês P. Moreira; Ivan Ramos Sasselli; Daniel A. Cannon; Meghan Hughes; Dimitrios A. Lamprou; Tell Tuttle; Rein V. Ulijn

    Soft Matter 2016 12 2623.

  • 74. Tripeptide Emulsifiers

    A series of tripeptides are shown to form emulsions with sequence tunable properties. Using a combination of simulations and experiments, it is shown that two types of oil-in-water emulsions may be produced, either forming stable interfacial nanofiber networks with remarkable stability, or more conventional surfactant-like monolayers.

    Gary G. Scott; Paul J. McKnight; Tell Tuttle; Rein V. Ulijn

    Adv. Materials 2016 28 1329