• 89. Cooperative, ion-sensitive co-assembly of tripeptide hydrogels

    Computational simulations and experimental validation of cooperative co-assembly of structural and functional tripeptides shows selective hydrogel formation in response to complexation with copper.

    Abul-Haija, Y. M.; Scott, G. G.; Sahoo, J. K.; Tuttle, T.; Ulijn, R. V.

    Chem. Commun. 2017 53 9562.

  • 88. Molecular dynamics simulations reveal disruptive self-assembly in dynamic peptide libraries

    There is significant interest in the use of unmodified self-assembling peptides as building blocks for functional, supramolecular biomaterials. Recently, dynamic peptide libraries (DPLs) have been proposed to select self-assembling materials from dynamically exchanging mixtures of dipeptide inputs in the presence of a nonspecific protease enzyme, where peptide sequences are selected and amplified based on their […]

    Sasselli, I. R.; Moreira, I. P.; Ulijn, R. V.; T. Tuttle, T.

    Org. Biomol. Chem. 2017 15 6541.

  • 87. Iridium-Catalyzed Formyl-Selective Deuteration of Aldehydes

    We report the first direct catalytic method for formyl-selective deuterium labeling of aromatic aldehydes under mild conditions, using an iridium-based catalyst designed to favor formyl over aromatic C−H activation. A good range of aromatic aldehydes is selectively labeled, and a one-pot labeling/olefination method is also described. Computational studies support kinetic product control over competing aromatic […]

    Kerr, W. J.; Reid, M.; Tuttle, T.

    Angew. Chem. Int. Ed. 2017 56 7808.

  • 86. Polymeric peptide pigments with sequence-encoded properties

    Melanins are a family of heterogeneous polymeric pigments that provide ultraviolet (UV) light protection, structural support, coloration, and free radical scavenging. Formed by oxidative oligomerization of catecholic small molecules, the physical properties of melanins are influenced by covalent and noncovalent disorder. We report the use of tyrosine-containing tripeptides as tunable precursors for polymeric pigments. In […]

    Lampel, A.; McPhee, S. A.; Park, H-A.; Scott, G. G.; Humagain, S.; Hekstra, D. R.; Barney Yoo, B.; Frederix, P. W. J. M.; Li, T-D.; Abzalimov, R. R.; Greenbaum, S. G.; Tuttle, T.; Hu, C.; Betting, C. J.; Ulijn, R. V.

    Science 2017 356 1064.