100 Club
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78. KOtBu: A Privileged Reagent for Electron Transfer Reactions?
J. Am. Chem. Soc. 2016 138 7402.
J. Am. Chem. Soc. 2016 138 7402.
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67. Exploring the sequence space for (tri-)peptide self-assembly to design and discover new hydrogels
Peptides that self-assemble into nanostructures are of tremendous interest for biological, medical, photonic and nanotechnological applications. The enormous sequence space that is available from 20 amino acids probably harbours many interesting candidates, but it is currently not possible to predict supramolecular behaviour from sequence alone. Here, we demonstrate computational tools to screen for the aqueous […]
Nature Chem. 2015 7 30
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66. Iridium-Catalyzed C-H Activation and Deuteration of Primary Sulfonamides: an Experimental and Computational Study
Iridium-catalyzed C-H activation and ortho-hydrogen isotope exchange is an important technology for allowing access to labelled organic substrates and aromatic drug molecules, and for the development of further C-H activation processes in organic synthesis. The use of [(COD)Ir(NHC)Cl] complexes (NHC = N-heterocyclic carbene) in the ortho-deuteration of primary sulfonamides under ambient conditions is reported. This […]
ACS Catal. 2015 5 402
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65. Identifying the Roles of Amino Acids, Alcohols and 1,2-Diamines as Mediators in Coupling of Haloarenes to Arenes
Coupling of haloarenes to arenes has been facilitated by a diverse range of organic additives in the presence of KOtBu or NaOtBu since the first report in 2008. Very recently, we showed that the reactivity of some of these additives (e.g. compounds 6 and 7 in Figure 1) could be explained by the formation of […]
J. Am. Chem. Soc. 2014 136 17818
